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Intrinsic or intrarenal
acute renal failure (ARF) occurs when direct damage to
the kidneys causes a sudden loss in kidney function. The treatment of intrinsic
acute renal failure includes identifying and correcting the cause of the renal
failure. The most common causes of intrinsic acute renal failure are acute
tubular necrosis (ATN), acute glomerulonephritis (AGN), and
acute interstitial nephritis (AIN).
Acute tubular necrosis
(ATN) is a condition in which the small filtering tubes in the kidney are
injured. ATN is a common cause of intrinsic acute renal failure often seen in
people who are already hospitalized. ATN may occur because of:
a condition in which the tiny blood vessels in the kidneys become inflamed and
damaged. Damaged glomeruli do not filter blood properly.
glomerulonephritis may be caused by an abnormal
immune system response. Some specific conditions that
cause acute glomerulonephritis include:
Symptoms of glomerulonephritis include blood and protein in
the urine, high blood pressure, and swelling caused by fluid retention
interstitial nephritis (AIN) is inflammation of the kidneys. It is usually
caused by a
medicine, such as an
antibiotic or a
nonsteroidal anti-inflammatory drug like aspirin or
ibuprofen. But AIN may also be caused by a streptococcal, viral, or
Symptoms of AIN
include a skin rash, fever, and an abnormal sediment in the urine.
May 10, 2011
E. Gregory Thompson, MD - Internal Medicine & Tushar J. Vachharajani, MD, FASN, FACP - Nephrology
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