Skip to Content

View Additional Content In This Section

Cushing's Syndrome: Corticotropin-Releasing Hormone

Topic Overview

The corticotropin-releasing hormone (CRH) stimulation test helps determine whether a pituitary tumor may be causing Cushing's syndrome. It is sometimes done with an inferior petrosal sinus sampling (IPSS) test.

In these tests, a small tube (catheter) is used to collect samples from blood vessels coming from the pituitary gland near the brain and also from a vein in your arm. You will get an injection of CRH, and samples of your blood near your pituitary gland and from your arm are taken.

If these blood samples show high levels of adrenocorticotropic hormone (ACTH) and cortisol, it usually indicates that the pituitary gland has a tumor.

If blood levels of ACTH and cortisol do not rise, your doctor may then look for an adrenal tumor or a cancerous tumor elsewhere in your body.

Related Information

Credits

By Healthwise Staff
E. Gregory Thompson, MD - Internal Medicine
David C.W. Lau, MD, PhD, FRCPC - Endocrinology
Last Revised January 10, 2012

This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.

© 1995-2014 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.

2650 Siskiyou Blvd., Medford, OR 97504

541-789-7000